Current research projects include:

• Melatonin signaling and translational use of melatonin in prostate cancer therapy

• Targeting sPDZD2 signaling for tumor suppression

• Tam, C.W., Chan, K.W., Liu,V.W. S., Pang, B., Yao, K.-M. and Shiu, S.Y.W. (2008) Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance. Journal of Pineal Research 45, 403-412.
  
  
• Tam, C.W., Liu, V.W.S, Leung, W.Y., Yao, K.-M. and Shiu, S.Y.W. (2008) The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53. Cancer Letters 271, 64-80.



• Shiu, S.Y.W. (2007) Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment. Journal of Pineal Research 43, 1-9.
  
  
• Tam, C.W., Mo, C.W., Yao, K.-M. and Shiu, S.Y.W. (2007) Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention. Journal of Pineal Research 42, 191-202.
  
  
• Tam, C.W., Cheng, A.S., Ma, R.Y.M., Yao, K.-M. and Shiu, S.Y.W. (2006) Inhibition of prostate cancer cell growth by human sPDZD2 protein, a potential autocrine prostate tumor suppressor. Endocrinology 147, 5023-5033.
  
  
• Shiu, S.Y.W., Law, I.C., Lau, K.W., Tam, P.C., Yip, A.W.C. and Ng, W.T. (2003) Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. Journal of Pineal Research 35, 177-182.



• Siu, S.W.F., Lau, K.W., Tam, P.C. and Shiu, S.Y.W. (2002) Melatonin and prostate cancer cell proliferation: Interplay with castration, epidermal growth factor, and androgen sensitivity. Prostate 52: 106-122 (Erratum in: Prostate 2002; 52: 252).
  
  
• Xi, S.C., Siu, S.W.F., Fong, S.W. and Shiu, S.Y.W. (2001) Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of anti-proliferative action of the pineal hormone with mt1 receptor protein expression. Prostate 46, 52-61.



• Xi, S.C., Tam, P.C., Brown, G.M., Pang, S.F. and Shiu, S.Y.W. (2000) Potential involvement of mt1 receptor and attenuated sex steroid-induced calcium influx in the direct anti-proliferative action of melatonin on androgen-responsive LNCaP human prostate cancer cells. Journal of Pineal Research 29, 172-183.