Hao, Quan

郝權

Professor

e-mail: qhao@hku.hk

Tel.: 2819-9194

• BSc (Physics), University of Science Technology of China (USTC), 1984.
• PhD (Physics), Institute of Physics, Chinese Academy of Sciences, 1988.
• Postdoc fellow, University of York (UK), 1988-1991.
• Postdoc fellow, Daresbury Laboratory & University of Liverpool (UK), 1991-1994.
• Lecturer/Senior Lecturer in Biophysics, De Montfort University (UK), 1994-2001.
• Director of Macromolecular Crystallography at the Cornell High Energy Synchrotron Source MacCHESS Cornell University, USA, 2001-08

• A molecular envelope based crystallographic phasing method
• Novel post-translational modifications by sirtuins
• Protein targets in infectious diseases and molecular mechanism of microbe-host interactions

• JT Du, YY Zhou, XY Su, JJ Yu, S Khan, H Jiang, J Kim, J Woo, JH Kim, BH Choi, B He, S Zhang, RA Cerione, J Auwerx, Q Hao* and HL Lin* (2011) Science, Vol. 334, 806-809. Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase.


• HM Zhang* and Q Hao* (2011) The FASEB Journal, vol. 25, 2574-2582. Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism.


• HM Zhang, R Graeff, Z Chen, LR Zhang, LH Zhang, HC Lee* & Q Hao* (2011) J. Mol. Biol. Vol. 405: 1070-1078. Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal.


• Q Liu, R Graeff, IA. Kriksunov, H Jiang, B Zhang, N Oppenheimer, H Lin, BVL Potter, HC Lee*, and Q Hao* (2009) J. Biol. Chem., Vol. 284: 27637-27645. Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase.


• R Graeff, Q Liu, IA Kriksunov, M Kotaka, N Oppenheimer, Q Hao* and HC Lee* (2009) J. Biol. Chem., Vol. 284: 27629-27636. Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38.(Cover feature, Paper of the Week)


• Q. Liu, IA Kriksunov, R. Graeff, HC Lee*, and Q. Hao* (2007) J. Biol. Chem., Vol. 282, 5853-5861 begin_of_the_skype_highlightingend_of_the_skype_highlighting. Structural basis for formation and hydrolysis of calcium messenger cyclic ADP-ribose by human CD38.


• Q Hao* (2006) Acta Cryst. D62, 909-914. Macromolecular envelope determination and envelope-based phasing. (Journal Cover)


• N Yan, J. Chai, ES Lee, L. Gu, Q. Liu, J. He, JW Wu, D. Kokel, H. Li, Q. Hao, D. Xue and Y. Shi (2005) Nature, 437, 831-837. Structure of the CED-4−CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.


• Q Liu, IA Kriksunov, R. Graeff, C. Munshi, HC. Lee*, and Q. Hao* (2005) Structure, vol. 13, 1331-1339. Crystal Structure of Human CD38 Extracellular Domain. (Journal cover)


• Q. Hao* (2001), Acta Cryst. D57. 1410-1414. "Phasing from an Envelope". (Journal Cover)